Cadmium, Environmental Exposure and Health Outcomes
Web page from Environmental Health Perspectives (EHP) added 06 October 2009. Published on 04 November 2009 0 comments
Primary Topic: Environmental Chemicals
Secondary Topics: Public Health
Format: Web page
Document Type: Report
If the content is out of date or if a link is broken then please sign up or sign in to report this entry
- Bioavailability of ingested cadmium has been confirmed in studies on subjects with elevated dietary exposure and it is strengthened by the substantial amounts of cadmium accumulation in kidneys, eyes and other tissues and organs of environmentally exposed individuals. It is hypothesized that such accumulation results from the efficient absorption and systemic transport of cadmium, employing multiple transporters that are used for the body’s acquisition of calcium, iron, zinc and manganese. Adverse effects of cadmium on kidney and bone have been observed in environmentally exposed populations at the frequencies higher than those predicted from models of exposure. There is increasing evidence implicating cadmium in the risk of diseases that involve other tissues and organ systems at cadmium concentrations not producing effects on bone or renal function.